Association between SNP-genotype and chronic lymphocytic leukemia outcome in a randomized chemotherapy trial

نویسندگان

  • Rachel Wade
  • Maria Chiara Di Bernardo
  • Sue Richards
  • Davide Rossi
  • Dalemari Crowther-Swanepoel
  • Gianluca Gaidano
  • David G. Oscier
  • Daniel Catovsky
  • Richard S. Houlston
چکیده

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Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.

BACKGROUND There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently the same stage of disease. Identifying genetic variants that influence patients' outcome and response to treatment may provide important insights into the biology of the disease. DESIGN AND METHODS We investigated the possibility that genetic variation influences outcome by conducting ...

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Background: Patients with B-cell chronic lymphocytic leukemia (B-CLL) have hetero-geneous clinical courses, thus several biological parameters need to be added to the cur-rent clinical staging systems to predict disease outcome. Recent immunophenotypic stud-ies performed mainly in Western populations have demonstrated the prognostic value of CD38 and ZAP-70 expression in B-CLL. Objectives: To i...

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تاریخ انتشار 2011